136281-41-9

Upstream product

• 136281-40-8 ethyl 6-chloro-1,2-dihydro-1-methyl-4-(3,4-dimethoxyphenyl)-2-oxo-3quinolinecarboxylate 
• 136281-39-5 ethyl 6-chloro-1,2-dihydro-4-(3,4-dimethoxyphenyl)-2-oxo-3-quinolinecarboxylate 
• 94100-07-9 2-amino-5-chloro-3',4'-dimethoxybenzophenone 

Downstream Products

• 1026631-13-9 6-Chloro-4-(3,4-dimethoxy-phenyl)-3-isocyanato-1-methyl-1H-quinolin-2-one 

Relevant academic research and scientific papers

Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent Acyl-CoA: Cholesterol acyltransferase inhibitors

Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA: cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC50 values at the 10-8 to 10-9 M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.

Quinoline derivatives, their production and use

A quinoline derivative of the formula (I): STR1 wherein each phenyl ring of A, B and C can have one or more substituents, X is STR2 (R1 is a hydrogen atom or a lower alkyl group) or STR3 (R2 is a lower alkyl group or a lower alkoxy g