1362849-67-9Relevant academic research and scientific papers
Pinacolborane as the boron source in nitrogen-directed borylations of aromatic N, N -dimethylhydrazones
López-Rodríguez, Rocío,Ros, Abel,Fernández, Rosario,Lassaletta, José M.
, p. 9915 - 9920 (2012)
A mild procedure for the Ir(III)-catalyzed nitrogen-directed ortho borylation of aromatic N,N-dialkylhydrazones using pinacolborane as the boron source has been developed. The methodology relies on a modified, hemilabile N,N ligand built on a 4-N,N-dimethylaminopyridine unit that provides high reactivity while maintaining exclusive ortho-selectivity. This procedure can be combined with Suzuki-Miyaura cross-couplings in a 'one-pot' fashion to afford functionalized biaryl derivatives that, upon subsequent 'one-pot', high yielding transformations, provide a convenient entry for the preparation of advanced benzonitrile intermediates for the synthesis of Sartan-type drugs.
