136312-26-0Relevant articles and documents
Diasteroselective cyclizations with enantiopure malonaldehyde monocycloacetals
Bi, Lanrong,Zhao, Ming,Wang, Chao,Peng, Shiqi,Winterfeldt, Ekkehard
, p. 22 - 26 (2007/10/03)
The synthesis of a series of enantiopure malonaldehyde monocycloacetals is described. Treatment of 8b with L-tryptophan methyl ester, 5-methoxytryptamine, and tryptamine, respectively, in the Pictet-Spengler condensation gave the corresponding enantiomerically pure key precursors 1-3 and 17-21 in only two steps. Using a chiral amino-diol successfully realized the kinetic resolution of racemic carbolines 23 and 24.