136315-70-3Relevant articles and documents
Amipurimycin: Total Synthesis of the Proposed Structures and Diastereoisomers
Wang, Shengyang,Sun, Jiansong,Zhang, Qingju,Cao, Xin,Zhao, Yachen,Tang, Gongli,Yu, Biao
supporting information, p. 2884 - 2888 (2018/02/16)
The proposed diastereoisomers (1 a–d) together with their C8′-epimers (1 e–h) of amipurimycin, a unique antifungal peptidyl nucleoside antibiotic, have been synthesized for the first time. The synthetic approach is efficient and stereodivergent, and features a stereoselective aldol condensation to build the branched C9 sugar amino acid skeleton and a regio- and stereocontrolled gold(I)-catalyzed N-glycosylation to furnish the purine nucleoside. Analysis of the NMR data suggests that the previously assigned configuration of the tertiary C3′ in amipurimycin should be of opposite configuration.
A concise synthesis of rigidified β-amino acids via sulfanyl radical addition-cyclization of oxime ethers and hydrazones
Miyata, Okiko,Muroya, Kanami,Koide, Junko,Naito, Takeaki
, p. 271 - 272 (2007/10/03)
A new route to the rigidified cyclic β-amino acids such as cispentacin has been developed by sulfanyl radical addition-cyclization of the alkenyl-tethered-oxime ethers and hydrazones.