1363161-16-3Relevant articles and documents
FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF
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, (2021/04/02)
The present disclosure relates to a class of fused pyrimidine compounds of Formula I, their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to a process of preparation of these fused pyrimidine compounds, and to pharmaceutical compositions containing them.
Pyrimidinone compound and composition prepared from pyrimidinone compound
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, (2019/08/02)
The invention relates to the technical field of chemical medicine, and particularly discloses a pyrimidinone compound, a pharmaceutical composition prepared from the pyrimidinone compound and application of the pyrimidinone compound. The structural formula of the pyrimidinone compound is as follows: the pyrimidinone compound disclosed by the invention can serve as a protease inhibitor and furtherinhibit multiple kinds of tumor cells from growth effectively, generates an inhibiting effect on the protease of EGFR and Her families such as EGFR L858R/T790M and EGFR E745_A750/T790, can be used forpreparing antitumor drugs and overcome drug resistance induced by current drugs. The compound, to which the invention is related, and a pharmaceutically acceptable composition of the compound can beused for preparing the antitumor drugs for mankind and other mammals.
INHIBITORS OF EGFR AND/OR HER2 AND METHODS OF USE
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, (2019/03/17)
The application relates to a compound having Formula X: which modulates the activity of HER2 and/or a mutant thereof, and/or EGFR and/or a mutant thereof, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disea