1363173-34-5

Basic information

• Product Name: 1-Methyl-1H-indazole-3-carboxylic Acid Anhydride
• Synonyms: 1-Methyl-1H-indazole-3-carboxylic Acid Anhydride;WXKUAYVKUKAIQR-UHFFFAOYSA-N;Granisetron EP impurity I
• CAS NO: 1363173-34-5
• Molecular Formula: C18H14N4O3
• Molecular Weight: 334.32876
• Product Categories: Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1363173-34-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 557.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -1.93±0.50(Predicted)
• CAS DataBase Reference: 1-Methyl-1H-indazole-3-carboxylic Acid Anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-indazole-3-carboxylic Acid Anhydride(1363173-34-5)
• EPA Substance Registry System: 1-Methyl-1H-indazole-3-carboxylic Acid Anhydride(1363173-34-5)

Safety Data

• Hazardous Substances Data: 1363173-34-5(Hazardous Substances Data)

Usage

Uses

1-Methyl-1H-indazole-3-carboxylic Acid Anhydride is an impurity of Granisetron (G780000), a specific serotonin (5HT3) receptor antagonist and a antiemetic agent.

Upstream product

• 50890-83-0 1-methyl-1H-indazole-3-carboxylic acid 

Relevant articles and documents

Efficient syntheses of exo-granisetron hydrochloride and other potential impurities present in granisetron hydrochloride, an anti-emetic drug

European Pharmacopeia mentions about nine potential impurities in Granisetron hydrochloride. These impurities need to be controlled in the API as described in the Pharmacopeia. Elegant syntheses of four potential impurities in Granisetron hydrochloride are disclosed.