13632-07-0

Basic information

• Product Name: 5-acetamido-2-methylbenzenesulphonyl chloride
• Synonyms: 5-acetamido-2-methylbenzenesulphonyl chloride;Einecs 237-118-9;5-AcetaMido-2-Methylbenzene-1-sulfonyl chloride
• CAS NO: 13632-07-0
• Molecular Formula: C₉H₁₀ClNO₃S
• Molecular Weight: 247.6986
• EINECS: 237-118-9
• Mol File: 13632-07-0.mol

Chemical Properties

• Melting Point: 120-124 °C
• Boiling Point: 435.4°Cat760mmHg
• Flash Point: 217.1°C
• Appearance: /
• Density: 1.411g/cm³
• Vapor Pressure: 8.79E-08mmHg at 25°C
• Refractive Index: 1.575
• PKA: 14.09±0.70(Predicted)
• CAS DataBase Reference: 5-acetamido-2-methylbenzenesulphonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-acetamido-2-methylbenzenesulphonyl chloride(13632-07-0)
• EPA Substance Registry System: 5-acetamido-2-methylbenzenesulphonyl chloride(13632-07-0)

Safety Data

• Hazardous Substances Data: 13632-07-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
5-acetamido-2-methylbenzenesulphonyl chloride is utilized as a reagent for the introduction of sulfonyl groups into organic molecules. Its ability to readily form sulfonyl linkages makes it a valuable component in the creation of complex organic structures.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 5-acetamido-2-methylbenzenesulphonyl chloride is employed as a key intermediate in the synthesis of various drugs. Its sulfonyl chloride functionality allows for the formation of sulfonamide groups, which are common in a range of medicinal compounds.
Used in Agrochemical Manufacturing:
5-acetamido-2-methylbenzenesulphonyl chloride also finds application in the agrochemical sector, where it serves as a precursor for the development of compounds with pesticidal properties. Its reactivity enables the creation of sulfonyl-containing agrochemicals that can be tailored for specific applications.
Used in Dye Production:
In the dye industry, 5-acetamido-2-methylbenzenesulphonyl chloride is used as a starting material for the production of dyes with specific color characteristics. The sulfonyl group contributes to the dye's stability and color intensity.
Used in the Manufacture of Fine Chemicals:
5-acetamido-2-methylbenzenesulphonyl chloride is also employed in the production of fine chemicals, where its unique chemical properties are leveraged to create specialty compounds for various applications, including but not limited to, research, analytical chemistry, and the development of new materials.

InChI:InChI=1/C9H10ClNO3S/c1-6-3-4-8(11-7(2)12)5-9(6)15(10,13)14/h3-5H,1-2H3,(H,11,12)

Upstream product

• 103-89-9 4-Methylacetanilide 
• 7790-94-5 chlorosulfonic acid 

Downstream Products

• 102878-31-9 acetic acid-(3-mercapto-4-methyl-anilide) 
• 861611-34-9 bis-(5-acetylamino-2-methyl-phenyl)-disulfide 
• 200266-64-4 4-acetylamino-toluene-2-sulfonic acid amide 
• 958031-86-2 4-methyl-3-(2,2,2-trifluoroethylthio)aniline 
• 1353889-34-5 N-(3-(2-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-1-methylhydrazinylsulfonyl)-4-methylphenyl)acetamide 
• 860752-06-3 4,4'-dimethyl-3,3'-disulfanediyl-di-aniline 
• 861611-30-5 acetic acid-(4-methyl-5-methylsulfanyl-2-nitro-anilide) 
• 855941-88-7 acetic acid-(3-methanesulfonyl-4-methyl-anilide) 
• 861611-28-1 acetic acid-(3-methanesulfinyl-4-methyl-anilide) 

Relevant articles and documents

ALKYLPHENYLSULPHIDE DERIVATIVE AND PEST CONTROL AGENT

An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. [in the above formula, R1 is, for example, a C1～C6 alkyl group which is mono- or poly-substituted with halogen atom; R2 is, for example, a halogen atom or a C1～C6 alkyl group; R3 is, for example, a hydrogen atom or a halogen atom; and R4 is, for example, a hydrogen atom or a C1～C12 alkyl group.] The derivative or the salt has an excellent pest control effect.

Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR

Structure-activity relationship studies of the pyrazolo[1,5-a]pyridine class of PI3 kinase inhibitors show that substitution off the hydrazone nitrogen and replacement of the sulfonyl both gave a loss of p110α selectivity, with the exception of an N-hydroxyethyl analogue. Limited substitutions were tolerated around the phenyl ring; in particular the 2,5-substitution pattern was important for PI3 kinase activity. The N-hydroxyethyl compound also showed good inhibition of cell proliferation and inhibition of phosphorylation of Akt/PKB, a downstream marker of PI3 kinase activity. It had suitable pharmacokinetics for evaluation in vivo, and showed tumour growth inhibition in two human tumour cell lines in xenograft studies. This work has provided suggestions for the design of more soluble analogues.

PHENYL SULFONAMIDE ENDOTHELIN ANTAGONISTS

Compounds of the formula STR1 inhibit the activity of endothelin. The symbols are defined as follows: R 1, R 2 and R. sup.3 are each independently(a) hydrogen, except that R. sup.1 is other than hydrogen;(b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z 1, Z 2 and Z. sup.3 ;(c) halo;(d) hydroxyl;(e) cyano; (f) nitro; (g)--C(O)H or--C(O)R 6 ;(h)--CO 2 H or--CO 2 R 6 ; (i)--SH,--S(O) n R 6,--S(O) m--OH,--S(O) m--OR 6,--O--S(O) m--R 6,--O--S(O) m OH or--O--S(O) m--OR. sup.6 ;(j)--Z. sup.4--NR 7 R 8 ; or (k)--Z 4--N(R 11--Z 5--NR 9 R 10 ; and the remaining symbols are as defined in the specification.