13632-46-7

Upstream product

• 120-66-1 N-(2-methylphenyl)acetamide 

Downstream Products

• 108012-68-6 3-acetylamino-4-methyl-benzenesulfonic acid-(5-isopropyl-[1,3,4]thiadiazol-2-ylamide) 
• 6274-28-8 3-amino-4-methylbenzenesulfonamide 
• 105337-63-1 3-amino-4-methyl-benzenesulfonic acid-(5-isopropyl-[1,3,4]thiadiazol-2-ylamide) 
• 1078790-20-1 6-chloro-1-[3'-(N-acetamido)-4'-methylbenzenesulfonyl]-1H-indole 
• 926664-15-5 1-(3-acetamido-4-methyl)benzenesulfonyl indole 
• 1245240-45-2 C₁₅H₁₅BrN₂O₃S 
• 1078790-21-2 6-chloro-1-(3'-amino-4'-methylbenzenesulfonyl)-1H-indole 

Relevant academic research and scientific papers

Design, synthesis and pharmacological evaluation of indolylsulfonamide amines as potent and selective 5-HT6 receptor antagonists

A series of N′-[3-(indole-1-sulfonyl) aryl]-N,N-dimethyl ethane-1,2-diamines and N′-[3-(indole-1-sulfonyl) aryl]-N,N-dimethyl propane-1,3-diamines was designed and synthesized as 5-HT6 receptor ligands. These compounds, when screened in a functional reporter gene-based assay, displayed potent antagonistic activity with Kb values in the range of 1.8-60 nM. The lead compound 9y has shown good ADME surrogate properties, acceptable pharmacokinetic profile and is active in animal models of cognition like novel object recognition test and Morris water maze. It was selected for detailed profiling.

Aminoaryl sulphonamide derivatives as functional 5-HT6 ligands

The present invention provides aminoaryl sulphonamide derivatives of formula (I), useful in the treatment of a CNS disorder related to or affected by the 5-HT6 receptor. Pharmacological profiles of these components include high affinity binding with 5-HT6 receptors along with good selectivity towards the receptor. The present invention also includes stereoisomers, the salts, methods of preparation and medicine containing the aminoaryl sulphonamide derivatives.

AMINOALKOXY ARYL SULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS

The present invention relates to novel aminoalkoxy arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. These compounds are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, genito-urological disorders, cardiovascular diseases and cancer.

AMINOARYL SULPHONAMIDE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS.

The present invention provides aminoaryl sulphonamide derivatives of formula (I), useful in the treatment of a CNS disorder related to or affected by the 5-HTg receptor. Pharmacological profile of these compounds includes high affinity binding with 5-HTg receptor along with good selectivity towards the said receptor. The present invention also includes the stereoisomers, the salts, methods of preparation and medicine containing the said aminoaryl sulphonamide derivatives.