13632-89-8Relevant academic research and scientific papers
Carbocupration/zinc carbenoid homologation and β-elimination reactions for a new synthesis of allenes - Application to the enantioselective synthesis of chiral allenes by deracemization of sp3-organometallic derivatives
Varghese, Jos P.,Zouev, Irena,Aufauvre, Lionel,Knochel, Paul,Marek, Ilan
, p. 4151 - 4158 (2007/10/03)
A new and straightforward carbocupration/zinc homologation/β-elimination reaction sequence allows the one-pot synthesis of polysubstituted allenes from acetylenic sulfoxides in excellent isolated chemical yields. Secondary zinc carbenoids were used for the homologation reaction, and so a new synthesis of 1,1-diiodoalkanes is described. This methodology also allows the synthesis of chiral allenes through thermodynamic equilibration of secondary organometallic derivatives. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002.
