1363261-66-8

Basic information

• Product Name: (S)-N(α)-acetyl-2-(3-fluorophenyl)tryptophan methyl ester
• Synonyms: (S)-N(α)-acetyl-2-(3-fluorophenyl)tryptophan methyl ester
• CAS NO: 1363261-66-8
• Molecular Weight: 354.381
• Mol File: 1363261-66-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-N(α)-acetyl-2-(3-fluorophenyl)tryptophan methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N(α)-acetyl-2-(3-fluorophenyl)tryptophan methyl ester(1363261-66-8)
• EPA Substance Registry System: (S)-N(α)-acetyl-2-(3-fluorophenyl)tryptophan methyl ester(1363261-66-8)

Safety Data

• Hazardous Substances Data: 1363261-66-8(Hazardous Substances Data)

Upstream product

• 35356-70-8 Methyl 2-acetamidoacrylate 
• 124643-63-6 2-(3-fluorophenyl)-1H-indole 

Relevant articles and documents

Enantioselective synthesis of tryptophan derivatives by a tandem friedel-crafts conjugate addition/asymmetric protonation reaction

The tandem Friedel-Crafts conjugate addition/asymmetric protonation reaction between 2-substituted indoles and methyl 2-acetamidoacrylate is reported. The reaction is catalyzed by (R)-3,3′-dibromo-BINOL in the presence of stoichiometric SnCl4, and is the first example of a tandem conjugate addition/asymmetric protonation reaction using a BINOLSnCl4 complex as the catalyst. A range of indoles furnished synthetic tryptophan derivatives in good yields and high levels of enantioselectivity, even on a preparative scale. The convergent nature of this transformation should lend itself to the preparation of unnatural tryptophan derivatives for use in a broad array of synthetic and biological applications.