1363337-11-4Relevant academic research and scientific papers
Asymmetric aza-Michael addition under ultra-high pressure: Short bias to polyhydroxylated piperidines
Moura, Sidnei,Thomassigny, Christine,Ligeour, Caroline,Greck, Christine,Joseph, Delphine,Drege, Emmanuelle,Dumas, Franoise
scheme or table, p. 1812 - 1818 (2011/10/02)
Two polyhydroxylated piperidines have been prepared in short sequences from diacetone gluco- and allofuranose. The key step is a piezo-aza-Michael addition of diphenylmethanamine to enoates bearing a sugar moiety in the γ-position. The combination of ultra-high pressure associated to the presence of readily available sugars chiral pool led to the expected chiral amines in good yields and excellent stereoselectivities.
