136337-98-9

Basic information

• Product Name: 2-(2-Amino-phenylamino)-4,6-dimethyl-nicotinonitrile
• CAS NO: 136337-98-9
• Molecular Weight: 238.292
• Mol File: 136337-98-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-Amino-phenylamino)-4,6-dimethyl-nicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Amino-phenylamino)-4,6-dimethyl-nicotinonitrile(136337-98-9)
• EPA Substance Registry System: 2-(2-Amino-phenylamino)-4,6-dimethyl-nicotinonitrile(136337-98-9)

Safety Data

• Hazardous Substances Data: 136337-98-9(Hazardous Substances Data)

Upstream product

• 14237-71-9 2-chloro-4,6-dimethylnicotinonitrile 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

A synthesis of pyridobenzodiazepines

2-Chloro-4,6-dimethylnicotinonitrile (I) has been prepared and allowed to react with 1,2-phenylenediamine and its dimethyl derivative in abs. ethanol to produce 2-arylaminonicotinonitrile derivatives (II) through dehydrohalogenation.When the nitriles (II) are heated at their melting points they suffer intramolecular nucleophilic cycloaddition to give pyridobenzodiazepines (III).However, fusion of 1,2-phenylenediamines with I affords a mixture of II and III-hydrochlorides.The free bases (III) are leberated from their hydrochlorides by neutralization with sodium carbonate.Structures of the new compounds have been established by microanalytical and spectroscopic data.