136338-02-8

Basic information

• Product Name: 2,4-Dimethyl-11H-benzo[b]pyrido[2,3-e][1,4]diazepin-5-ylamine; hydrochloride
• CAS NO: 136338-02-8
• Molecular Weight: 274.753
• Mol File: 136338-02-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-Dimethyl-11H-benzo[b]pyrido[2,3-e][1,4]diazepin-5-ylamine; hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethyl-11H-benzo[b]pyrido[2,3-e][1,4]diazepin-5-ylamine; hydrochloride(136338-02-8)
• EPA Substance Registry System: 2,4-Dimethyl-11H-benzo[b]pyrido[2,3-e][1,4]diazepin-5-ylamine; hydrochloride(136338-02-8)

Safety Data

• Hazardous Substances Data: 136338-02-8(Hazardous Substances Data)

Upstream product

• 14237-71-9 2-chloro-4,6-dimethylnicotinonitrile 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

A synthesis of pyridobenzodiazepines

2-Chloro-4,6-dimethylnicotinonitrile (I) has been prepared and allowed to react with 1,2-phenylenediamine and its dimethyl derivative in abs. ethanol to produce 2-arylaminonicotinonitrile derivatives (II) through dehydrohalogenation.When the nitriles (II) are heated at their melting points they suffer intramolecular nucleophilic cycloaddition to give pyridobenzodiazepines (III).However, fusion of 1,2-phenylenediamines with I affords a mixture of II and III-hydrochlorides.The free bases (III) are leberated from their hydrochlorides by neutralization with sodium carbonate.Structures of the new compounds have been established by microanalytical and spectroscopic data.