1363381-82-1 Usage
Uses
Used in Pharmaceutical Synthesis:
5-bromo-3-methoxy-1H-pyrazolo[3,4-b]pyridine is used as a key intermediate in the synthesis of various pharmaceuticals for its unique structure and reactivity. It contributes to the development of new drugs by providing a foundation for the creation of molecules with specific therapeutic properties.
Used in Agrochemical Development:
In the agrochemical industry, 5-bromo-3-methoxy-1H-pyrazolo[3,4-b]pyridine is utilized as a building block for the synthesis of new agrochemicals, such as pesticides and herbicides. Its incorporation into these products can enhance their effectiveness and selectivity in controlling pests and weeds.
Used in Drug Discovery:
5-bromo-3-methoxy-1H-pyrazolo[3,4-b]pyridine is employed as a kinase inhibitor in drug discovery. Its biological activity makes it a promising candidate for the development of targeted therapies against various diseases, including cancer and inflammatory conditions.
Used in Medicinal Chemistry Research:
5-bromo-3-methoxy-1H-pyrazolo[3,4-b]pyridine is used as a versatile molecule in organic synthesis and medicinal chemistry research. Its unique structure allows for the exploration of new synthetic pathways and the modification of its properties to enhance its therapeutic potential or to improve its pharmacokinetic profile.
Check Digit Verification of cas no
The CAS Registry Mumber 1363381-82-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,3,3,8 and 1 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1363381-82:
(9*1)+(8*3)+(7*6)+(6*3)+(5*3)+(4*8)+(3*1)+(2*8)+(1*2)=161
161 % 10 = 1
So 1363381-82-1 is a valid CAS Registry Number.
1363381-82-1Relevant academic research and scientific papers
Li, Yingjun,Cheng, Huimin,Zhang, Zhang,Zhuang, Xiaoxi,Luo, Jinfeng,Long, Huoyou,Zhou, Yang,Xu, Yong,Taghipouran, Rana,Li, Dan,Patterson, Adam,Smaill, Jeff,Tu, Zhengchao,Wu, Donghai,Ren, Xiaomei,Ding, Ke
, p. 543 - 547 (2015)
A series of N-(3-ethynyl-2,4-difluorophenyl)sulfonamides were identified as new selective Raf inhibitors. The compounds potently inhibit B-RafV600E with low nanomolar IC50 values and exhibit excellent target specificity in a selectivity profiling investigation against 468 kinases. They strongly suppress proliferation of a panel of human cancer cell lines and patient-derived melanoma cells with B-RafV600E mutation while being significantly less potent to the cells with B-RafWT. The compounds also display favorable pharmacokinetic properties with a preferred example (3s) demonstrating significant in vivo antitumor efficacy in a xenograft mouse model of B-RafV600E mutated Colo205 human colorectal cancer cells, supporting it as a promising lead compound for further anticancer drug discovery.
