1363393-15-0Relevant academic research and scientific papers
Synthesis and bioactivity of imidazo [2,1-6]-1,3,4-thiadiazolo [2,3-c]-s-triazoles, s-triazolo [3,4-6]-1,3,4-thiadiazolo [3,2-6] imidazo [4,5-b] quinoxaline and bis-(s-triazolo [3,4-b]-1,3,4-thiadiazolo [3,2-b] [imidazo [4,5-to] cyclohexane]-5a,6a-diene)
Mohan, Jag,Rathee, Anju
, p. 121 - 124 (2013/09/24)
Condensation of 4-amino-5-mercapto-3-(m-chlorophenyl)-s-triazole 1 with cyanogen bromide gives 6-amino-3-(m-chlorophenyl)-s-triazolo [3,4-6]-1,3,4-thiadiazole 2 which on condensation with chloranil yields 3,9-di-(m-chlorophenyl)-6,14-dioxo-bis-(s-triazolo [3,4-b]-1,3,4-thiadiazolo [3,2-b] [imidazo [4,5-b] cyclohexane]-5a, 6a-diene) 3. 3-(m-Chlorophenyl)-s- triazolo [3,4-b]-1,3,4-thiadiazolo [3,2-b] imidazo [4,5-b] quinoxaline 4 is obtained by a similar condensation of 2 with 2,3-dichloroquinoxaline. The reaction of 2 with α-haloketones followed by bromination affords 7-aryl-3-(mchlorophenyl)-imidazo [2,1-b]-1,3,4-thiadiazolo [2,3-c]-s-triazoles 5 and their 6-bromo analogues 6 respectively. The antibacterial and antifungal activities of some of the compounds have also been evaluated.
