1363394-58-4

Upstream product

• 133129-56-3 1,2-dimethoxy-4-(methoxymethoxy)benzene 
• 91142-24-4 1-ethynyl-4-isopropoxybenzene 
• 1363394-53-9 C₂₀H₂₆O₄ 
• 1363394-52-8 C₂₁H₂₆O₅ 
• 1363394-49-3 C₁₀H₁₂O₅ 
• 1363394-47-1 C₁₂H₁₆O₆ 
• 1363394-57-3 3-(3-bromo-4-methoxyphenyl)-7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinoline 
• 1363394-56-2 2-bromo-4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol 
• 1363394-55-1 4-(7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinolin-3-yl)phenol 
• 1363394-54-0 3-(4-isopropoxyphenyl)-7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinoline 
• 1363394-51-7 6-(4-isopropoxyphenethyl)-2,3-dimethoxybenzaldehyde 
• 1363394-50-6 methyl 6-((4-isopropoxyphenyl)ethynyl)-2,3-dimethoxybenzoate 
• 1363394-48-2 methyl 2,3-dimethoxy-6-(trifluoromethylsulfonyloxy)benzoate 

Downstream Products

• 1363394-60-8 3-(3,4-dimethoxyphenyl)-7,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 1363394-59-5 3-(3,4-dimethoxyphenyl)-7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Concise route to 3-arylisoquinoline skeleton by lewis acid catalyzed c(sp3)-h bond functionalization and its application to formal synthesis of (±)-Tetrahydropalmatine

An expeditious route to furnish an isoquinoline skeleton via hydride shift mediated C-H bond functionalization was developed. In this process, an unusual [1,5]-H shift without the assistance of the adjacent heteroatom took place to produce tetrahydroisoquinoline derivatives in good to excellent chemical yields. The formal synthesis of (±)-tetrahydropalmatine was achieved by exploiting this new transformation.