1363401-03-9Relevant academic research and scientific papers
Enantioselective organocatalytic addition of azlactones to maleimides: A highly stereocontrolled entry to 2,2-Disubstituted-2H-oxazol-5-ones
Alba, Andrea-Nekane R.,Valero, Guillem,Calbet, Teresa,Font-Bardia, Merce,Moyano, Albert,Rios, Ramon
, p. 9884 - 9889 (2010)
The first highly diastereo- and enantioselective organocatalytic synthesis of 2,2-disubstituted-2H-oxazol-5-ones is described. The addition of oxazolones to maleimides is promoted by bifunctional thiourea catalysts, which afford the corresponding 2,2-disubstituted-2H-oxazol-5-ones with total regio- and stereocontrol.
