136343-72-1Relevant academic research and scientific papers
On the importance of an acid additive in the synthesis of pyrido[1,2-a]benzimidazoles by direct copper-catalyzed amination
Masters, Kye-Simeon,Rauws, Tom R. M.,Yadav, Ashok K.,Herrebout, Wouter A.,Van Der Veken, Benjamin,Maes, Bert U. W.
, p. 6315 - 6320 (2011)
Not just an acid! An expedient and highly modular synthesis of 6-, 7-, and 8-substituted pyrido[1,2-a]benzimidazoles (4) has been developed by a direct intramolecular C-H amination of N-phenylpyridin-2-amines (3). Efficient C-H amination of 3 could only be achieved in the presence of catalytic copper and an acid additive. The type of acid (pKa) proved to be crucial for the catalysis. C-Cl aminations in N-(2-chloroaryl)pyridin-2-amines allow access to 9-substituted pyrido[1,2-a]benzimidazoles. Copyright
PHOTOCYCLIZATION OF HETEROARENES
Baklanov, M. V.,Frolov, A. N.
, p. 550 - 559 (2007/10/02)
The new reaction of the photocyclization of heteroarenes is described.It leads to the formation of condensed imidazoles with various structures.The relation of the acid-base properties to the course of the alkylation reaction was studied.For the case of 8-chlorodipyridoimidazole it was shown that mono- and diprotonation goes at the atom N5, but methylation at the atoms N5 and N6.
