1363594-47-1 Usage
Description
Dithiobutylamine, synthesized from L-aspartic acid, is a potent and versatile disulfide-reducing agent. It possesses the ability to reduce the enzyme papain, which has a relatively anionic active site, at a rate 14 times faster than DTT.
Uses
Used in Enzyme Reduction:
Dithiobutylamine is used as a disulfide-reducing agent for the reduction of enzymes, such as papain, due to its high efficiency in reducing disulfide bonds at a faster rate compared to other agents like DTT.
Used in Pharmaceutical Industry:
Dithiobutylamine is used as a key component in the development of pharmaceuticals, particularly for applications involving enzyme reduction and stabilization, as its rapid reduction capability can enhance the effectiveness of certain drugs and therapies.
Used in Biochemical Research:
In the field of biochemical research, Dithiobutylamine is utilized as a valuable tool for studying the structure and function of proteins and enzymes, as well as for investigating the role of disulfide bonds in various biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 1363594-47-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,3,5,9 and 4 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1363594-47:
(9*1)+(8*3)+(7*6)+(6*3)+(5*5)+(4*9)+(3*4)+(2*4)+(1*7)=181
181 % 10 = 1
So 1363594-47-1 is a valid CAS Registry Number.
1363594-47-1Relevant articles and documents
Thiols and selenols as electron-relay catalysts for disulfide-bond reduction
Lukesh III, John C.,VanVeller, Brett,Raines, Ronald T.
, p. 12901 - 12904 (2013)
Pass them on! Dithiobutylamine immobilized on a resin is a useful reagent for the reduction of disulfide bonds. Its ability to reduce a disulfide bond in a protein is enhanced greatly if used along with a soluble strained cyclic disulfide or mixed diselenide that relays electrons from the resin to the protein. This electron-relay catalysis system provides distinct advantages over the use of excess soluble reducing agent alone. Copyright
