1363683-75-3Relevant academic research and scientific papers
Novel chiral thiazoline-containing NO ligands in the asymmetric addition of diethylzinc to aldehydes: Substituent effect on the enantioselectivity
Gong, Zhiyong,Liu, Qingwen,Xue, Pengchong,Li, Kechang,Song, Zhiguang,Liu, Zaiqun,Jin, Yinghua
, p. 121 - 129 (2012)
Several novel chiral thiazoline primary and tertiary alcohols were easily synthesized from commercially available l-cysteine in three steps and with high yield. These ligands were subsequently applied to the asymmetric addition of diethylzinc (Et2Zn) to various aldehydes. Products with S configuration were obtained when thiazoline-containing tertiary alcohol ligands were used as catalysts. The primary alcohol induced corresponding products with R configuration in 68% enantiomeric excess, which was a higher value relative to other NO ligands possessing a primary alcohol unit in the literature. Furthermore, a plausible transition state model was proposed to explain the observed enantioselectivities. Copyright
