13640-51-2

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-2-(pyridin-3-ylmethylidene)-3,4-dihydronaphthalen-1(2H)-one is used as an intermediate in the synthesis of various pharmaceuticals due to its potential biological activity, such as antimicrobial and anticancer properties.
Used in Dye Industry:
(2E)-2-(pyridin-3-ylmethylidene)-3,4-dihydronaphthalen-1(2H)-one is used as a precursor in the production of dyes, taking advantage of its unique chemical structure and color properties.
Used in Agrochemical Industry:
(2E)-2-(pyridin-3-ylmethylidene)-3,4-dihydronaphthalen-1(2H)-one is used in the development of agrochemicals, such as pesticides and herbicides, due to its potential biological activity and ability to target specific pests or weeds.

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 

Downstream Products

• 109329-58-0 3-(4-Chloro-phenyl)-4-pyridin-3-yl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 
• 109329-61-5 3-(4-Methoxy-phenyl)-4-pyridin-3-yl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 
• 109329-51-3 3-Phenyl-4-pyridin-3-yl-3,4,5,6-tetrahydro-1H-benzo[h]quinolin-2-one 

Relevant academic research and scientific papers

Synthesis of Some Multi-cyclic Sulfhydryl Donor Compounds Containing 1,2-dithiol-3-thione moiety

1,2-Dithiol-3-thiones are a sulfur containing five membered heterocyclic compounds, which constitute an important class of biologically active compounds owing to their ability to release sulfhydryl (SH) group. In this research a new series of multi-cyclic

Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine playing crucial role in immunity. MIF exerts a unique tautomerase enzymatic activity that has relevance concerning its multiple functions and its small molecule inhibitors have been proven to block its pro-inflammatory effects. Here we demonstrate that some of the E-2-arylmethylene-1-tetralones and their heteroanalogues efficiently bind to MIF’s active site and inhibit MIF tautomeric (enolase, ketolase activity) functions. A small set of the synthesised derivatives, namely compounds (4), (23), (24), (26) and (32), reduced inflammatory macrophage activation. Two of the selected compounds (24) and (26), however, markedly inhibited ROS and nitrite production, NF-κB activation, TNF-α, IL-6 and CCL-2 cytokine expression. Pre-treatment of mice with compound (24) exaggerated the hypothermic response to high dose of bacterial endotoxin. Our experiments suggest that tetralones and their derivatives inhibit MIF’s tautomeric functions and regulate macrophage activation and thermal changes in severe forms of systemic inflammation.

Synthesis and in vitro evaluation of 2-heteroarylidene-1-tetralone derivatives as monoamine oxidase inhibitors

The present study investigates the human monoamine oxidase (MAO) inhibition properties of a series of twelve 2-hetero-arylidene-1-tetralone derivatives. Also included are related cyclohexylmethylidene, cyclopentylmethylidene and ben-zylidene substituted 1

Tetrahydronaphthalenes: Influence of heterocyclic substituents on inhibition of steroidogenic enzymes P450 arom and P450 17

In search of new leads for selective inhibition of estrogen and androgen biosynthesis, respectively, heterocyclic substituted 2-(arylmethylene)-1- tetralones (1-4, 9-17), 2-(arylhydroxymethyl)-1-tetralones (5-8), exo- 1a,2,3,7b-tetrahydro-1H-cyclopropa[a]