1364031-16-2Relevant academic research and scientific papers
Sequential suzuki-miyaura cross-coupling reactions of 4-halopyrazolyl MIDA 3-boronates: A modular synthetic entry to 3,4-bis(hetero)aromatic pyrazoles
Delaunay, Thierry,Es-Sayed, Mazen,Vors, Jean-Pierre,Monteiro, Nuno,Balme, Genevieve
, p. 1434 - 1436 (2013/05/08)
The 1,3-dipolar cycloaddition of N-arylsydnones with ethynyl MIDA boronate produces mixtures of the corresponding regioisomeric pyrazolyl 3(4)-boronates, with the pyrazolyl 3-boronates predominating by a factor of 7:3. Further C-4 iodination of the latter opened access to 4-iodopyrazolyl MIDA 3-boronates as valuable scaffolds for the elaboration of unsymmetrically 1,3,4-trisubstituted pyrazole derivatives via Suzuki cross-coupling reactions.
