1364041-48-4Relevant academic research and scientific papers
Chiral squaramides catalyzed diastereo- and enantioselective Michael addition of α-substituted isocyanoacetates to N-aryl maleimides
Zhao, Mei-Xin,Ji, Fei-Hu,Wei, Deng-Ke,Shi, Min
, p. 10763 - 10771 (2013/12/04)
An efficient diastereo- and enantioselective Michael addition of α-substituted isocyanoacetates to N-aryl maleimides catalyzed by quinine or cyclohexane-1,2-diamine derived squaramide catalysts has been disclosed, affording the corresponding adducts in go
Asymmetric michael addition of α-substituted isocyanoacetates with maleimides catalyzed by chiral tertiary amine thiourea
Bai, Jian-Fei,Wang, Liang-Liang,Peng, Lin,Guo, Yun-Long,Jia, Li-Na,Tian, Fang,He, Guang-Yun,Xu, Xiao-Ying,Wang, Li-Xin
experimental part, p. 2947 - 2953 (2012/05/20)
A highly diastereoselective and enantioselective Michael addition of α-substituted isocyanoacetates with maleimides catalyzed by bifunctional tertiary amine thioureas has been developed. Various chiral succinimide derivatives bearing adjacent quaternary and tertiary stereocenters were prepared in excellent yields (up to 98%), diastereoselectivities (up to 99:1), and enantioselectivities (up to 98% ee). The synthetic utility of chiral succinimide derivatives is also demonstrated in the preparation of h5-HT1d receptor agonist motifs.
