136409-75-1

Upstream product

• 142706-48-7 1-((2R,3S,4R,5R)-3-Hydroxy-5-hydroxymethyl-4-phenylselanyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 1666-13-3 diphenyl diselenide 
• 134100-03-1 1-(3-deoxy-3-phenylseleno-2,5-di-O-pivaloyl-β-D-xylofuranosyl)uracil 
• 134100-02-0 3'-O-mesyl-2',5'-di-O-pivaloyluridine 

Downstream Products

• 132364-17-1 1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-β-D-glycero-pento-2-enofuranosyl]uracil 

Relevant academic research and scientific papers

Uracil and Adenine Nucleosides Having a 2',3'-Bromovinyl Structure: Highly Versatile Synthons for the Synthesis of 2'-C- and 3'-C-Branched 2',3'-Unsaturated Derivatives

Preparation of 2'- and 3'-bromo derivatives of 2',3'-unsaturated uracil and adenine nucleosides has been carried out starting from the corresponding β-hydroxyselenides by way of bromination and successive selenoxide elimination.These compounds have been shown to serve as versatile synthons for the preparation of anti-HIV candidates, 2'-C- and 3'-C-branched 2',3'-unsaturated nucleosides, through palladium-catalyzed cross-coupling and halogen-lithium exchange reactions. Key Words: β-hydroxyselenide; bromovinyl structure; branched-sugar nucleoside; anti-HIV agent; 2',3'-unsaturated nucleoside.