136410-26-9Relevant articles and documents
N -Acyliminium Ion Chemistry: Improving the Access to Unsaturated γ-Lactams and Their N -α-Methoxylated Derivatives: Application to an Expeditive Synthesis of (±)-Crispine A
Drici, Wassila,Fayssal, Sandra Abi,Lazouni, Imane,Pérard-Viret, Jo?lle,Souquet, Florence,Thueillon, Sébastien
, p. 2970 - 2978 (2020/10/18)
An improved synthesis of unsaturated γ-lactams by condensation of various primary amines with 2,5-dimethoxy-2,5-dihydrofuran is described. A modified mechanism for this reaction is suggested. Synthesis of their N -α-methoxylated derivatives, as N -acyliminium ion precursors, is also reported. Finally, a short synthesis of (±)-crispine A is presented as an illustrative application.
Selective Ruthenium-Catalyzed Reductive Alkoxylation and Amination of Cyclic Imides
Cabrero-Antonino, Jose R.,Sorribes, Ivn,Junge, Kathrin,Beller, Matthias
supporting information, p. 387 - 391 (2016/01/25)
Reported herein, for the first time, is the selective ruthenium-catalyzed reductive alkoxylation and amination of phthalimides/succinimides. Notably, this novel methodology avoids hydrogenation of the aromatic ring and allows methoxylation of substituted imides with good to excellent selectivity for one of the carbonyl groups. The reported method opens the door to the development of new processes for the selective synthesis of various functionalized N-heterocyclic compounds. As an example, intramolecular reductive couplings to afford tricyclic compounds are presented for the first time.
Amnesia-reversal activity of a series of 5-alkoxy-1-arylcarbonyl-2-pyrrolidinones and 5-alkoxy-1-arylmethyl-2-pyrrolidinones
Toja, E,Gorini, C,Zirotti, C,Barzaghi, F,Galliani, G
, p. 415 - 422 (2007/10/02)
A series of 5-alkoxy-1-arylcarbonyl-2-pyrrolidinones (1-27) were prepared by condensation of arylcarbonyl chlorides with 5-alkoxy-2-pyrrolidinones in the presence of butyl lithium in tetrahydrofuran.Alkylation of these intermediates with substituted benzy
