1364142-75-5Relevant academic research and scientific papers
High-pressure accelerated asymmetric organocatalytic friedel-crafts alkylation of indoles with enones: Application to quaternary stereogenic centers construction
Lyzwa, Dawid,Dudzinski, Krzysztof,Kwiatkowski, Piotr
supporting information; experimental part, p. 1540 - 1543 (2012/06/15)
An organocatalytic Friedel-Crafts alkylation of indoles with α,β-unsaturated ketones was found to be efficiently accelerated under high-pressure conditions with a low loading of chiral primary amine salts with good yield and enantioselectivity up to 90%. This approach also allows, for the first time, selected indole derivatives containing quaternary stereogenic centers to be obtained from prochiral β,β-disubstituted enones with an enantioselectivity up to 80%.
