136423-87-5Relevant academic research and scientific papers
SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION
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Paragraph 0200; 0202, (2013/07/19)
Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
Guanylhydrazones of 3-substituted 2-pyridinecarboxaldehyde and of (2-substituted 3-pyridinyloxy) acetaldehyde as prostanoid biosynthesis and platelet aggregation inhibitors
Desideri, N,Sestili, I,Manarini, S,Cerletti, C,Stein, ML
, p. 455 - 460 (2007/10/02)
Some guanylhydrazones of (3-benzyloxy)-2-pyridinecarboxaldehyde and of (2-substituted 3-pyridinyloxy)acetaldehyde were prepared in order to evaluate their possible activity as inhibitors of prostanoid biosynthesis in human serum.Only those products of the second group without the carboxylic function reduced prostanoid generation in vitro at the highest concentration; they also inhibited platelet aggregation induced by arachidonic acid and U-46619.The results suggest that these compounds are both inhibitors of cyclooxygenase and cyclic endoperoxides/TxA2 platelet receptor antagonists.
