1364268-90-5 Usage
Chemical Structure
It consists of a benzamide derivative with a pyridine and thiophene ring system.
Biological Activity
Potential kinase inhibitor
Therapeutic Potential
Particularly in cancer treatment or other disease states where kinase inhibitors are useful
Research Status
Further research is needed to fully understand its potential uses and effects.
Check Digit Verification of cas no
The CAS Registry Mumber 1364268-90-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,4,2,6 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1364268-90:
(9*1)+(8*3)+(7*6)+(6*4)+(5*2)+(4*6)+(3*8)+(2*9)+(1*0)=175
175 % 10 = 5
So 1364268-90-5 is a valid CAS Registry Number.
1364268-90-5Relevant articles and documents
Design of potent and selective hybrid inhibitors of the mitotic kinase nek2: Structure-activity relationship, structural biology, and cellular activity
Innocenti, Paolo,Cheung, Kwai-Ming J.,Solanki, Savade,Mas-Droux, Corine,Rowan, Fiona,Yeoh, Sharon,Boxall, Kathy,Westlake, Maura,Pickard, Lisa,Hardy, Tara,Baxter, Joanne E.,Aherne, G. Wynne,Bayliss, Richard,Fry, Andrew M.,Hoelder, Swen
, p. 3228 - 3241 (2012/06/01)
We report herein a series of Nek2 inhibitors based on an aminopyridine scaffold. These compounds have been designed by combining key elements of two previously discovered chemical series. Structure based design led to aminopyridine (R)-21, a potent and selective inhibitor able to modulate Nek2 activity in cells.
