1364511-80-7Relevant academic research and scientific papers
Organocatalytic oxidative annulation of benzamide derivatives with alkynes
Manna, Srimanta,Antonchick, Andrey P.
supporting information, p. 7324 - 7327 (2014/07/21)
Organocatalytic annulation by functionalization of benzamide derivatives with alkynes has been developed. We report a new approach of cycloaddition under mild reaction conditions using simple catalysts, such as iodobenzene and peracetic acid, as oxidant. Those novel, mild reaction conditions provided a straightforward synthesis of isoquinolones with fast reaction rate. Notable selectivity in annulation of unsymmetrically disubstituted alkynes was demonstrated.
A practical one-pot procedure for the synthesis of N-H isoquinolones
Lu, Shaonan,Lin, Yingfu,Zhong, Hongban,Zhao, Kang,Huang, Jianhui
supporting information, p. 2001 - 2005 (2013/04/23)
A practical one-pot procedure for the preparation of N-H isoquinolones has been developed. This 2-step process via C-H activation of N-alkoxyl benzamides and NaH-mediated dealkoxylation reaction has been demonstrated to be a high yielding alternative meth
Pd-catalysed synthesis of isoquinolinones and analogues via C-H and N-H bonds double activation
Zhong, Hongban,Yang, Dan,Wang, Songqing,Huang, Jianhui
supporting information; experimental part, p. 3236 - 3238 (2012/04/11)
An atom economical synthesis of isoquinolinones and analogues via ligand-free Pd-catalysed C-H and N-H double activation has been developed. A series of isoquinolinones were obtained in good to excellent yields. Good regioselectivities were also observed during the activation reactions with unsymmetrical alkynes. A practical one-pot procedure for the preparation of N-H isoquinolinones is also described. The Royal Society of Chemistry 2012.
