1364525-21-2

Basic information

• Product Name: C₁₅H₁₉F₃N₂O₂
• Synonyms: C₁₅H₁₉F₃N₂O₂
• CAS NO: 1364525-21-2
• Molecular Weight: 316.323
• Mol File: 1364525-21-2.mol

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₉F₃N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₉F₃N₂O₂(1364525-21-2)
• EPA Substance Registry System: C₁₅H₁₉F₃N₂O₂(1364525-21-2)

Safety Data

• Hazardous Substances Data: 1364525-21-2(Hazardous Substances Data)

Upstream product

• 407-25-0 trifluoroacetic anhydride 
• 144881-51-6 1-(4-isopropoxyphenyl)piperazine 

Downstream Products

• 1364525-13-2 1-(trifluoromethyl)-4-(4-isopropoxy-3-nitrophenyl)piperazine 
• 1609122-95-3 N-(5-(4-benzylpiperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609122-96-4 N-(5-(4-(4-nitrobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609122-97-5 N-(5-(4-(3-nitrobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609122-98-6 N-(5-(4-(2-nitrobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609122-99-7 N-(5-(4-(3,5-dinitrobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609123-00-3 N-(5-(4-(4-chlorobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609123-01-4 N-(5-(4-(4-cyanobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609123-02-5 N-(5-(4-(4-fluorobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609123-03-6 N-(5-(4-(4-bromobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609123-04-7 methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazin-1-yl)methyl)benzoate 
• 1609123-06-9 methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazine-1-yl)methyl)benzenesulfonate 
• 1609123-08-1 N-(5-(4-(4-methylbenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609123-09-2 N-(5-(4-(4-aminobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 

Relevant articles and documents

Design, syntheses, and characterization of piperazine based chemokine receptor CCR5 antagonists as anti prostate cancer agents

Chemokine receptor CCR5 plays an important role in the pro-inflammatory environment that aids in the proliferation of prostate cancer cells. Previously, a series of CCR5 antagonists containing a piperidine ring core skeleton were designed based upon the proposed CCR5 antagonist pharmacophore from molecular modeling studies. The developed CCR5 antagonists were able to antagonize CCR5 at a micromolar level and inhibit the proliferation of metastatic prostate cancer cell lines. In order to further explore the structure-activity-relationship of the pharmacophore identified, the molecular scaffold was expanded to contain a piperazine ring as the core. A number of compounds that were synthesized showed promising anti prostate cancer activity and reasonable cytotoxicity profiles based on the biological characterization.