1364663-36-4Relevant academic research and scientific papers
Optimized S-trityl-l-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models
Good, James A. D.,Wang, Fang,Rath, Oliver,Kaan, Hung Yi Kristal,Talapatra, Sandeep K.,Podgórski, Dawid,MacKay, Simon P.,Kozielski, Frank
, p. 1878 - 1893 (2013/05/08)
The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously, we identified S-trityl-l-cysteine as a selective inhibitor of Eg5 and developed triphenylbutanamine analogues with improved pot
Inhibition of hepatitis C virus NS5B polymerase by S-trityl-l-cysteine derivatives
Nichols, Daniel B.,Fournet, Guy,Gurukumar,Basu, Amartya,Lee, Jin-Ching,Sakamoto, Naoya,Kozielski, Frank,Musmuca, Ira,Joseph, Beno?t,Ragno, Rino,Kaushik-Basu, Neerja
experimental part, p. 191 - 199 (2012/03/27)
Structure-based studies led to the identification of a constrained derivative of S-trityl-l-cysteine (STLC) scaffold as a candidate inhibitor of hepatitis C virus (HCV) NS5B polymerase. A panel of STLC derivatives were synthesized and investigated for the
