136470-77-4

Basic information

• Product Name: Abacavir 5’-Phosphate
• Synonyms: Abacavir 5’-Phosphate;(1S,4R)- 4-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]-2-cyclopentene-1-Methanol Dihydrogen Phosphate (Ester);(1S-cis)-Abacavir Monophosphate
• CAS NO: 136470-77-4
• Molecular Formula: C14H19N6O4P
• Molecular Weight: 366.312221
• Product Categories: Bases & Related Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Nucleotides;Pharmaceuticals;Phosphorylating and Phosphitylating Agents
• Mol File: 136470-77-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 749.3±70.0 °C(Predicted)
• Appearance: /
• Density: 1.93±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Methanol, Water
• PKA: 1.91±0.10(Predicted)
• CAS DataBase Reference: Abacavir 5’-Phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: Abacavir 5’-Phosphate(136470-77-4)
• EPA Substance Registry System: Abacavir 5’-Phosphate(136470-77-4)

Safety Data

• Hazardous Substances Data: 136470-77-4(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 136470-77-4 differently. You can refer to the following data:
1. Abacavir 5’-Phosphate (Abacavir - In House Impurity) is a metabolite of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
2. A metabolite of Abacavir (A105000).