1364740-03-3Relevant academic research and scientific papers
Practical synthesis of a benzophenone-based NNRT inhibitor of HIV-1
Wang, Xiao-Jun,Zhang, Li,Sun, Xiufeng,Lee, Heewon,Krishnamurthy, Dhileepkumar,O'Meara, Jeff A.,Landry, Serge,Yoakim, Christiane,Simoneau, Bruno,Yee, Nathan K.,Senanayake, Chris H.
experimental part, p. 561 - 566 (2012/07/03)
A convergent synthesis of NNRTI 1 is described. The key step involves a direct coupling of acid chloride 4 with Grignard reagent 11 in the presence of bis[2-(N,N-dimethylamino)ethyl] ether that moderates the reactivity of the Grignard reagent to give benzophenone 7. An efficient 2-step process for the preparation of 2-fluoro-3-methyl-4-aminobenzoic acid (3) is also described.
