136479-92-0Relevant academic research and scientific papers
Asymmetric Reactions of Enamines with Methyl (E)-4-Oxo-4-(2-oxo-1,3-oxazolidin-3-yl)-2-butenoate by Use of a Chiral Titanium Reagent
Hayashi, Yujiro,Otaka, Ken,Saito, Nobuo,Narasaka, Koichi
, p. 2122 - 2127 (2007/10/02)
Asymmetric Michael and cycloaddition reactions between enamines and methyl (E)-4-oxo-4-(2-oxo-1,3-oxazolidin-3-yl)-2-butenoate proceed with a chiral titanium reagent generated in situ from dichlorodiisopropoxytitanium and a tartrate-derived chiral 1,4-diol.In the presence of excess amounts of the chiral titanium reagent, good to moderate enantioselectivity is attained.The reactions are also well catalyzed even with a catalytic amount of the titanium reagent.
