136484-03-2Relevant academic research and scientific papers
Bombesin receptor antagonists. 5 new irreversible alkylating analogues
De Castiglione,Gozzini,Galantino,Corradi,Ciomei,Roletto,Bertolero
, p. 855 - 867 (2007/10/02)
New alkylating bombesin analogues were synthesized in order to increase their solubility and stability in aqueous solutions. The best compromise between these parameters and the biological properties (receptor binding and antagonistic activity) was achieved with 4-[bis(2-chloro-ethylamino)]benzoyl derivatives of the BN (7-14) octapeptide carrying a (13-14) reduced peptide bond independently of the presence of a His12 residue, either free or protected.
