13650-49-2

Basic information

• Product Name: H-ORN(BOC)-OH
• Synonyms: ORNITHINE(BOC)-OH;N-DELTA-T-BOC-L-ORNITHINE;N-DELTA-T-BUTOXYCARBONYL-L-ORNITHINE;N-DELTA-TERT-BUTYLOXYCARBONYL-L-ORNITHINE;N-DELTA-BOC-L-ORNITHINE;N-EPSILON-T-BUTYLOXYCARBONYL-L-ORNITHINE;BOC-L-ORN-OH;H-L-ORN(BOC)-OH
• CAS NO: 13650-49-2
• Molecular Formula: C₁₀H₂₀N₂O₄
• Molecular Weight: 232.2768
• Product Categories: Amino Acids;A - H;Amino Acids;Modified Amino Acids
• Mol File: 13650-49-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 218-219℃
• Boiling Point: 401.522 °C at 760 mmHg
• Flash Point: 196.634 °C
• Appearance: /
• Density: 1.135
• Vapor Pressure: 1.43E-07mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: −20°C
• PKA: 2.51±0.24(Predicted)
• CAS DataBase Reference: H-ORN(BOC)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-ORN(BOC)-OH(13650-49-2)
• EPA Substance Registry System: H-ORN(BOC)-OH(13650-49-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 13650-49-2(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

Different sources of media describe the Uses of 13650-49-2 differently. You can refer to the following data:
1. N-δ-Boc-L-Ornithine is a boc-protected analogue of L-Orthinine (O695550), a non essential amino acid and intermediate in arginine biosynthesis. N-δ-Boc-L-Ornithine is used as an intermediate in the preparation of the protein arginine deiminase (PAD) inhibitor F-Amidine (F101250).
2. N-δ-Boc-L-Ornithine is a boc-protected analogue of L-Orthinine (O695550), a non essential amino acid and intermediate in arginine biosynthesis. N-δ-Boc-L-Ornithine is used as an intermediate in the pr eparation of the protein arginine deiminase (PAD) inhibitor F-Amidine (F101250).

InChI:InChI=1/C10H20N2O4/c1-10(2,3)16-9(15)12-6-4-5-7(11)8(13)14/h7H,4-6,11H2,1-3H3,(H,12,15)(H,13,14)

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 3184-13-2 L-ornithine hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7733-29-1 Z-Orn(Boc)-OH 
• 70-26-8 L-ornithine 

Downstream Products

• 7733-29-1 Z-Orn(Boc)-OH 
• 96846-16-1 N²-<4-<<(2,4-diamino-6-pteridinyl)methyl>methylamino>benzoyl>-N⁵-<(1,1-dimethylethoxy)carbonyl>-2,5-diaminopentanoic acid 
• 141397-64-0 N^δ-(tert-butyloxycarbonyl)-N^α-(5-deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine 
• 233690-09-0 2-benzylamino-5-tert-butoxycarbonylamino-pentanoic acid 
• 864531-92-0 5-tert-butoxycarbonylamino-2-(4-nitro-benzyloxycarbonylamino)-pentanoic acid 
• 1043444-25-2 N-α-benzoyl-N⁵-(tert-butoxycarbonyl)-L-ornithine 
• 109425-55-0 Fmoc-Orn(Boc)-OH 
• 1335096-64-4 N⁽²⁾-2-carboxylbenzoyl-N⁽⁵⁾-Boc-L-ornithine amide 
• 2640-58-6 Nα-benzyloxycarbonyl-L-ornithine 
• 1430816-72-0 C₁₉H₂₁N₃O₆ 
• 96846-20-7 (S)-5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoic acid; compound with trifluoro-acetic acid 
• 96845-99-7 N²-<4-(methylamino)benzoyl>-N^ω-<(1,1-dimethylethoxy)carbonyl>-2,ω-diaminopentanoic acid 
• 120296-65-3 N^α-(4-Amino-4-deoxy-5-chloro-5,8-dideazapteroyl)-N^δ-(tert-butyloxycarbonyl)-L-ornithine 
• 120296-64-2 N^δ-(tert-Butyloxycarbonyl)-N^α-(5-chloro-5,8-dideazapteroyl)-L-ornithine 

Relevant articles and documents

Three novel cantharidin-related compounds from the Chinese blister beetle, Mylabris phalerata PALL

Three novel cantharidin analogues were isolated from the Chinese blister beetle, Mylabris phalerata PALL. (Meloidae), which has been used in traditional Chinese medicine for the treatment of cancer. Their structures were determined on the basis of heteronuclear multiple-bond connectivity and nuclear Overhauser effect spectroscopy experiments, and chemical data confirmed them to be so-called cantharimides, in which the anhydride oxygen atoms are replaced by the basic amino acid L-lysine, L-ornithine, and L-arginine moieties.

Tri-peptide cationic lipids for gene delivery

Several novel tri-peptide cationic lipids were designed and synthesized for delivering DNA and siRNA. They have tri-lysine and tri-ornithine as headgroups, a carbamate group as a linker and 12 and 14 carbon atom alkyl groups as tails. These tri-peptide cationic lipids were prepared into cationic liposomes for the study of the physicochemical properties and gene delivery. Their particle size, zeta potential and DNA-binding were characterized to show that they were suitable for gene transfection. Further results indicate that these lipids can transfer DNA and siRNA very efficiently into NCI-H460 and Hep-2 tumor cells. The selected lipid, CDO14, was able to deliver combined siRNAs against c-Myc and VEGF for silencing distinct oncogenic pathways in lung tumors of mice, with little in vitro and in vivo toxicity. This journal is

Decomposition of copper-amino acid complexes by oxalic acid dihydrate

A facile approach to the synthesis of some side-chain-protected amino acids via oxalic acid dihydrate as the copper sequestering reagent is presented. The copper in the amino acid complex reacted with oxalic acid dihydrate to form insoluble cupric oxalate, with the free amino acid released. Compared with conventional methods, this method is convenient, inexpensive, and environmentally friendly.