13651-05-3Relevant articles and documents
Chemoselective bromination in a two-step substitution under the influence of tetrachlorosilane and N-bromosuccinimide
Elmorsy, Saad,Badawy, Doria,Khatab, Tamer
, p. 2005 - 2012 (2006)
The synthesis of gem dibromide carbonyl compounds via a cheep and readily available combined reagent from tetrachlorosilane and N-bromosuccinimide (TCS-NBS). Copyright Taylor & Francis Group, LLC.
Electrochemical Oxidative Functionalization of Arylalkynes: Access to α,α-Dibromo Aryl Ketones
Wang, Dan,Wan, Zhaohua,Zhang, Heng,Lei, Aiwen
supporting information, p. 1022 - 1027 (2020/12/31)
A general and effective protocol to synthesize α,α-dibromo aryl ketones has been developed via an electrochemical oxidative method. The reaction proceeds smoothly at room temperature in an undivided cell without the addition of external oxidants. In the reaction process, LiBr acts as both bromine source and supporting electrolyte. This electrooxidation strategy has good substrate applicability and functional group compatibility. Moreover, the reaction could be scaled up efficiently in a continuous flow cell. The target product could undergo further functionalization for the synthesis of some useful heterocyclic compounds. (Figure presented.).
Selective Debromination of α,α,α-Tribromomethylketones with HBr–H2O Reductive Catalytic System
Cheng, Zhao,Guo, Hongmei,Huang, Guozheng,Rexit, Abulikemu Abudu,Wang, Hui,Zheng, Meng-Xia
, p. 6455 - 6458 (2020/10/21)
A debromination of α,α,α-tribromomethylketones is developed for chemoselective synthesis of α-mono- and α,α-dibromomethylketones with high selectivity under H2O–HBr reductive conditions. This method offers an efficient and direct way to synthesize α-mono or α,α-dibromomethylketone compounds in high to excellent yields through the process of HBr self-circulation in water.
