136511-43-8

Basic information

• Product Name: ethyl N-[(2S)-3-(acetylsulfanyl)-2-(2-methylbenzyl)propanoyl]-L-methioninate
• CAS NO: 136511-43-8
• Molecular Formula: C₂₀H₂₉NO₄S₂
• Molecular Weight: 411.5786
• Mol File: 136511-43-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 597.3°C at 760 mmHg
• Flash Point: 315°C
• Density: 1.158g/cm³
• Vapor Pressure: 3.14E-14mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: ethyl N-[(2S)-3-(acetylsulfanyl)-2-(2-methylbenzyl)propanoyl]-L-methioninate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-[(2S)-3-(acetylsulfanyl)-2-(2-methylbenzyl)propanoyl]-L-methioninate(136511-43-8)
• EPA Substance Registry System: ethyl N-[(2S)-3-(acetylsulfanyl)-2-(2-methylbenzyl)propanoyl]-L-methioninate(136511-43-8)

Safety Data

• Hazardous Substances Data: 136511-43-8(Hazardous Substances Data)

Upstream product

• 2899-36-7 L-methionine ethyl ester monohydrochloride 
• 139263-23-3 2(S)-acetylthiomethyl-3-(2-methylphenyl)propionic acid 
• 156757-36-7 2-methyl-α-methylenebenzenepropanoic acid 

Relevant articles and documents

Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure- activity relationship studies of methionine and S-alkylcysteine derivatives

A broad series of N-(3-mercaptoacyl) amino acid derivatives was evaluated for their ability to inhibit atriopeptidase (neutral endopeptidase, EC 3.4.24.11) in vitro and in vivo. Structural parameters studied were (i) the substituent on the 2-position of the 3-mercaptopropionyl moiety, (ii) the amino acid component, (iii) the S-terminal derivative, and (iv) the C- terminal derivative. Optimum activity was observed for derivatives of methionine and S-alkylcysteines. N-[3-Mercapto-2(S)-[(2- methylphenyl)methyl]-1-oxopropyl]-L-methionine was identified as a highly effective inhibitor of atriopeptidase meriting evaluation as a potential cardiovascular therapeutic agent.