136521-57-8

Basic information

• Product Name: (S)-2-HYDROXY-2-(5-METHYLFURYL)ACETONITRILE
• Synonyms: (S)-2-HYDROXY-2-(5-METHYLFURYL)ACETONITRILE
• CAS NO: 136521-57-8
• Molecular Formula: C7H7NO2
• Molecular Weight: 0
• Mol File: 136521-57-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-HYDROXY-2-(5-METHYLFURYL)ACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-HYDROXY-2-(5-METHYLFURYL)ACETONITRILE(136521-57-8)
• EPA Substance Registry System: (S)-2-HYDROXY-2-(5-METHYLFURYL)ACETONITRILE(136521-57-8)

Safety Data

• Hazardous Substances Data: 136521-57-8(Hazardous Substances Data)

Usage

General Description

(S)-2-Hydroxy-2-(5-methylfurly)acetonitrile is a chemical compound with a molecular formula of C8H9NO2. It is a nitrile compound with both hydroxyl and furan functional groups, making it useful in a variety of organic synthesis applications. This chemical is commonly used as a building block for the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure also lends itself to being used as a chiral auxiliary in asymmetric synthesis reactions. Additionally, the presence of the furan ring makes it a potential precursor for the synthesis of heterocyclic compounds. Overall, (S)-2-Hydroxy-2-(5-methylfurly)acetonitrile has versatile applications in the field of organic chemistry and drug discovery.

Upstream product

• 620-02-0 5-Methylfurfural 
• 74-90-8 hydrogen cyanide 

Relevant articles and documents

Enantiomerically pure tetrahydroisoquinolines by enzyme catalysis and gold-catalyzed phenol synthesis

Five different furfural derivatives were converted to chiral cyanohydrins by enzyme catalysis in good enantiomeric excess. After a sequence of silyl protection, nitrile reduction, tosylation and propargylation, substrates for the gold(I) catalyzed cyclois

A study of asymmetric hydrocyanation of heteroaryl carboxaldehydes catalyzed by (R)-oxynitrilase under micro-aqueous conditions

A number of new optically active heteroaryl cyanohydrins have been prepared by hydrocyanation under micro-aqueous conditions catalyzed by almond meal (containing (R)-oxynitrilase). Substituent effects on the reaction are discussed. This micro-aqueous meth

Asymmetric Hydrocyanation of a Range of Aromatic and Aliphatic Aldehydes

A range of aryl, alkyl and heterocyclic aldehydes have been treated with hydrogen cyanide in the presence of the 'Inoue' catalyst, (R,R)- or (S,S)-cyclo.Most aryl aldehydes with electron-donating substituents in the m-or p-positions give high enantiomeric excess (e.e) values (>=80percent) but aryl aldehydes with strong electron-withdrawing substituents gave moderate e.e. values (=50percent).These moderate values are believed to be due to partial racemization of the product cyanohydrins in the presence of the mildly basic catalyst.In contrast to the reactions of aryl aldehydes, reactions of alkyl aldehydes and of ketones gave low e.e. values (=30percent) and an explanation is proposed.