136522-58-2Relevant academic research and scientific papers
Chiral Bicyclo[2.2.2]octane-Fused CpRh Complexes: Synthesis and Potential Use in Asymmetric C?H Activation
Li, Guozhu,Yan, Xiaoqiang,Jiang, Jijun,Liang, Hao,Zhou, Chao,Wang, Jun
, p. 22436 - 22440 (2020)
A new class of chiral cyclopentadienyl rhodium(I) complexes (CpRhI) bearing C2-symmetric chiral bridged-ring-fused Cp ligands was prepared. The complexes were successfully applied to the asymmetric C?H activation reaction of N-methoxybenzamides with quinones, affording a series of chiral hydrophenanthridinones in up to 82 % yield with up to 99 % ee. Interestingly, structure analysis reveals that the side wall of the optimal chiral CpRhI catalyst is vertically more extended, horizontally less extended, and closer to the metal center in comparison with the classic binaphthyl and spirobiindanyl CpRhI complexes, and may thus account for its superior catalytic performance.
Synthesis of optically active 2,5-dialkylcyclohexane-1,4-diols and their application in the asymmetric oxidation of sulfides
Sun, Jiangtao,Yang, Minghua,Dai, Zhenya,Zhu, Chengjian,Hu, Hongwen
experimental part, p. 2513 - 2518 (2009/04/11)
A simple and efficient approach to obtain optically pure 1,4-diols was established. The asymmetric oxidation of sulfides to sulfoxides with cumyl hydroperoxide in moderate yields and moderate to high enantioselectivities (up to 84%) catalyzed by chiral Ti/ 1,4-diols complexes has been achieved. A 76% ee value was obtained in the asymmetric synthesis of esomeprazole. Georg Thieme Verlag Stuttgart.
