1365265-06-0Relevant academic research and scientific papers
Fenton reagent-catalyzed trifluoromethylation of enamines of 3-oxocarboxylates with CF3I
Ohtsuka, Yuhki,Uraguchi, Daisuke,Yamamoto, Kyoko,Tokuhisa, Kenji,Yamakawa, Tetsu
, p. 1 - 6 (2016)
The trifluoromethylation of enamines of ethyl 3-oxocarboxylates catalyzed by Fenton reagent with CF3I was investigated. Trifluoromethylation followed by acid hydrolysis provided 3-oxo-2-(trifluoromethyl)carboxylates in 64-94% yields, which were greater than those obtained by the trifluoromethylation of 3-oxocarboxylates as reported previously. Enamines trifluoromethylated at the 2-position were isolated as intermediates. Hydrolysis and successive decarboxylation of the obtained 3-oxo-2-(trifluoromethyl)carboxylates under acidic conditions provided (2,2,2-trifluoroethyl)ketones in satisfactory yields.
METHOD FOR PRODUCING (2,2,2-TRIFLUOROETHYL)KETONE
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Paragraph 0139-0141, (2018/08/28)
PROBLEM TO BE SOLVED: To provide a method for efficiently producing (2,2,2-trifluoroethyl)ketone that is an important compound as a pharmaceutical fluorine-containing building block. SOLUTION: The method produces (2,2,2-trifluoroethyl)ketone represented by formula (3) by reacting 3-oxo-2-(trifluoromethyl)propanoic acid ester represented by formula (1) under the presence of an acid. (R1 is an alkyl group of C1 to 4; R2 is a C1 to 8 alkyl group, etc. substituted/un-substituted with F.) SELECTED DRAWING: None COPYRIGHT: (C)2016,JPO&INPIT
Syntheses of 2-(trifluoromethyl)-1,3-dicarbonyl compounds through direct trifluoromethylation with CF3I and their application to fluorinated pyrazoles syntheses
Ohtsuka, Yuhki,Uraguchi, Daisuke,Yamamoto, Kyoko,Tokuhisa, Kenji,Yamakawa, Tetsu
experimental part, p. 2636 - 2649 (2012/04/23)
Direct trifluoromethylation of 1,3-dicarbonyl compounds with CF 3I in the presence of a Fenton reagent in dimethylsulfoxide was investigated. 1,3-Diketones, 3-oxocarboxylates and 3-oxocarboxamides were readily trifluoromethylated at the methyle
