1365267-35-1

Basic information

• Product Name: Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-
• Synonyms: Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-;1,3-bis(((S)-2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)urea;Rivaroxaban Impurity 14;Imp. C:1,3-bis(((S)-2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)urea;Rivaroxaban impurity S-I;Rivaroxaban Urea Dimer;Rivaroxaban Urea Dimer Impurity;N,N'-Bis[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]urea
• CAS NO: 1365267-35-1
• Molecular Formula: C₂₉H₃₂N₆O₉
• Molecular Weight: 608.59918
• EINECS: -0
• Mol File: 1365267-35-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 993.6±65.0 °C(Predicted)
• Appearance: /
• Density: 1.423±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly, Sonicated), Methanol (Very Slightly, Heated)
• PKA: 13.02±0.46(Predicted)
• CAS DataBase Reference: Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-(1365267-35-1)
• EPA Substance Registry System: Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-(1365267-35-1)

Safety Data

• Hazardous Substances Data: 1365267-35-1(Hazardous Substances Data)

Usage

Uses

N,N’-Bis[Des(5-chloro-2-carvoxythienyl) Rivaroxaban] Urea is an impurity of Rivaroxaban (R538000), a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.

Upstream product

• 898543-06-1 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholin-3-one hydrochloride 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 446292-10-0 4-[4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl]morpholine-3-one 

Relevant articles and documents

A related substance [...] F, G synthetic method

The invention provides synthetic methods of related substances F and G of rivaroxaban. With the adoption of the synthetic methods of the related substances F and G of the rivaroxaban, the yield is high, and industrial production and technology transformation are realized easily.