1365350-16-8

Basic information

• Product Name: 8-amino-5-hydroxy-4-methyl-10-(4-methylphenyl)-2-oxo-2H,10H-pyrano[2,3-h]chromene-9-carbonitrile
• Synonyms: 8-amino-5-hydroxy-4-methyl-10-(4-methylphenyl)-2-oxo-2H,10H-pyrano[2,3-h]chromene-9-carbonitrile
• CAS NO: 1365350-16-8
• Molecular Weight: 360.369
• Mol File: 1365350-16-8.mol

Chemical Properties

• CAS DataBase Reference: 8-amino-5-hydroxy-4-methyl-10-(4-methylphenyl)-2-oxo-2H,10H-pyrano[2,3-h]chromene-9-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 8-amino-5-hydroxy-4-methyl-10-(4-methylphenyl)-2-oxo-2H,10H-pyrano[2,3-h]chromene-9-carbonitrile(1365350-16-8)
• EPA Substance Registry System: 8-amino-5-hydroxy-4-methyl-10-(4-methylphenyl)-2-oxo-2H,10H-pyrano[2,3-h]chromene-9-carbonitrile(1365350-16-8)

Safety Data

• Hazardous Substances Data: 1365350-16-8(Hazardous Substances Data)

Upstream product

• 2107-76-8 4-methyl-5,7-dihydroxycoumarin 
• 104-87-0 4-methyl-benzaldehyde 
• 109-77-3 malononitrile 

Relevant articles and documents

A one-pot, three-component synthesis of new pyrano[2,3-h]coumarin derivatives

The reaction between 5,7-dihydroxy-4-substituted coumarin, malononitrile, and aromatic aldehydes in the presence of a catalytic amount of K 2CO3 as a basic catalyst leads to new pyrano[2,3-h] coumarin derivatives in good to excellent

Nano-Fe3O4@SiO2-supported boron sulfonic acid as a novel magnetically heterogeneous catalyst for the synthesis of pyrano coumarins

In this study, a novel magnetically heterogeneous catalyst based on the immobilization of boron sulfonic acid onto Fe3O4@SiO2 nanoparticles (Fe3O4@SiO2-BSA) is reported. Fe3Osub

Alternative two-step route to khellactone analogues using silica tungstic acid and sodium hydrogen phosphate

A series of coumarins was synthesised via the silica tungstic acid-catalysed Pechmann reaction; some of these were employed for known three-component reactions with aromatic aldehydes and malononitrile in the presence of sodium hydrogen phosphate (Na2HPO4) as a basic catalyst, affording a variety of potentially anti-HIV active khellactone analogues.

Ionic-liquid-catalyzed green synthesis of coumarin derivatives under solvent-free conditions

Broensted acidic ionic liquids, namely 2-pyrrolidonium hydrogen sulfate, N-methyl-2-pyrrolidonium hydrogen sulfate, N-methyl-2-pyrrolidonium dihydrogen phosphate, (4-sulfobutyl)tris(4-sulfophenyl)phosphonium hydrogen sulfate, and triphenyl(propyl-3-sulfonyl)phosphonium toluenesulfonate, catalyzed efficient Pechmann condensation of phloroglucinol with β-keto ethyl/methyl esters. 5,7-Dihydroxy-4-methylcoumarin and 5,7-dihydroxy-4-phenylcoumarin were prepared in good to excellent yields under mild, ambient, and solvent-free conditions. Pyrano[2,3-h]coumarins were then prepared by one-pot three-component reactions of 5,7-dihydroxy-4-subsituted coumarin, malononitrile, and aldehydes in the presence of catalytic amounts of Broensted basic ionic liquids, namely 2-hydroxyethylammonium formate, 3-hydroxypropanaminium acetate, 1-butyl-3-methylimidazolium hydroxide, pyrrolidinium formate, and pyrrolidinium acetate, under thermal solvent-free conditions. The catalysts are environmentally benign and can be easily prepared, stored, and recovered without significant loss of activity.