136546-79-7Relevant academic research and scientific papers
Asymmetric Synthesis of Calyculin A. 2. The C26-C37 γ-Amino Acid Fragments
Evans, David A.,Gage, James R.,Leighton, James L.,Kim, Annette S.
, p. 1961 - 1963 (1992)
New chiral imide enolate alkylation, aldol, and Michael addition bond constructions have been employed in the asymmetric synthesis of the C26-C37 portion of calyculin A.
Stereoselective synthesis of rapamycin fragment to build a macrocyclic toolbox
Guduru, Shiva Krishna Reddy,Jimmidi, Ravikumar,Deora, Girdhar Singh,Arya, Prabhat
, p. 480 - 483 (2015)
A stereoselective synthesis of a rapamycin fragment is developed and further utilized toward building a macrocyclic chemical toolbox. The amino alcohol moiety embedded in the 22-membered macrocyclic ring allowed for the addition of a variation in the chir
Enantioselective Michael Reactions. Diastereoselective Reactions of Chlorotitanium Enolates of Chiral N-Acyloxazolidinones with Representative Electrophilic Olefins
Evans, David A.,Bilodeau, Mark T.,Somers, Todd C.,Clardy, Jon,Cherry, David,Kato, Yoko
, p. 5750 - 5752 (2007/10/02)
In the present study we wish to report the details of the diastereoselective reactions of titanium enolates derived from N-propionyloxazolidone 1 in inter- and intramolecular Michael reactions with ethyl vinyl ketone, methyl acrylate, and acrylonitrile (e
