1365530-40-0

Upstream product

• 1365530-33-1 5-bromo-25,26,27,28-tetrahydroxy-11,17,23-trisulfonatocalix[4]arene 
• 126747-14-6 4-cyanophenylboronic acid 
• 106774-58-7 25,26,27-tris(benzoyloxy)-28-hydroxycalix[4]arene 
• 317813-41-5 5-bromo-25,26,27,28-tetrahydroxy-calix[4]arene 
• 176098-91-2 25,26,27-tribenzoyloxy-5-bromo-28-hydroxycalix<4>arene 

Relevant academic research and scientific papers

METHOD AND ARRAY FOR IDENTIFYING HISTONE-CODE-RELATED ANALYTES

Disclosed embodiments concern an array for use in identifying or identifying and quantifying analytes in a sample using a macrocyclic sensor comprising a macrocyclic compound and a detectable moiety. The disclosed array may be used to discriminate among various analytes based on different features, such as post- translational modifications, isomeric post-translational modifications, and the peptide sequence around post-translational modifications. Also disclosed is a method for identifying analytes comprising a post-translational modification, as well as an enzymatic assay using the disclosed macrocyclic sensor.

Synthesis of new trisulfonated calix[4]arenes functionalized at the upper rim, and their complexation with the trimethyllysine epigenetic mark

A synthetic route to produce a new family of trisulfonated calix[4]arenes bearing a single group, selectively introduced, that lines the binding pocket is reported. Ten examples, including new sulfonamide and biphenyl-substituted hosts, each with additional binding elements, demonstrate the tuning of guest affinities and selectivities. NMR titrations in phosphate-buffered water show that one of the new hosts binds to the modified amino acid trimethyllysine with the highest affinity and selectivity observed to date.