1365564-56-2Relevant academic research and scientific papers
Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block
Torfoss, Veronika,Ausbacher, Dominik,Cavalcanti-Jacobsen, Cristiane de A.,Hansen, Terkel,Brandsdal, Bjorn-Olav,Havelkova, Martina,Strom, Morten B.
scheme or table, p. 170 - 176 (2012/06/29)
We report a series of synthetic anticancer heptapeptides (H-KKWβ2,2WKK-NH2) containing eight different central lipophilic β2,2-amino acid building blocks, which have demonstrated high efficiency when used as scaffolds in small cationic antimicrobial peptides and peptidomimetics. The most potent peptides in the present study had IC50 values of 9-23μm against human Burkitt's lymphoma and murine B-cell lymphoma and were all nonhaemolytic (EC50>200μm). The most promising peptide 10e also demonstrated low toxicity against human embryonic lung fibroblast cells and peripheral blood mononuclear cells and exceptional proteolytic stability.
