136558-13-9

Basic information

• Product Name: ETHYL 5-TERT-BUTYLTHIO-2,2-DIMETHYL-4-OXOPENTANOATE
• Synonyms: ETHYL 5-TERT-BUTYLTHIO-2,2-DIMETHYL-4-OXOPENTANOATE;5-(tert-Butylthio)-2,2-diMethyl-4-oxopentanoic Acid Ethyl Ester;5-[(1,1-DiMethylethyl)thio]-2,2-diMethyl-4-oxo-pentanoic Acid Ethyl Ester;Pentanoic acid, 5-[(1,1-diMethylethyl)thio]-2,2-diMethyl-4-oxo-, ethyl ester
• CAS NO: 136558-13-9
• Molecular Formula: C₁₃H₂₄O₃S
• Molecular Weight: 260.39
• Product Categories: Miscellaneous Reagents
• Mol File: 136558-13-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 110-132°C
• Appearance: /
• Density: 1.010±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: ETHYL 5-TERT-BUTYLTHIO-2,2-DIMETHYL-4-OXOPENTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-TERT-BUTYLTHIO-2,2-DIMETHYL-4-OXOPENTANOATE(136558-13-9)
• EPA Substance Registry System: ETHYL 5-TERT-BUTYLTHIO-2,2-DIMETHYL-4-OXOPENTANOATE(136558-13-9)

Safety Data

• Hazardous Substances Data: 136558-13-9(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Oil

Uses

Ethyl 5-tert-Butylthio-2,2-dimethyl-4-oxopentanoate (cas# 136558-13-9) is a compound useful in organic synthesis.

Upstream product

• 118427-36-4 ethyl 4-chloro-2,2-dimethyl-4-pentenoate 
• 97-62-1 Ethyl isobutyrate 
• 154325-75-4 5-bromo-2,2-dimethyl-4-oxopentanoic acid ethyl ester 
• 75-66-1 2-methylpropan-2-thiol 

Downstream Products

• 147961-24-8 3-[1-(4-Chlorobenzyl)-5-hydroxyindol-2-yl]-2,2-dimethylpropanoic acid 
• 154325-76-5 ethyl 3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-methoxyindol-2-yl]-2,2-dimethylpropionate 
• 1031435-50-3 1-bromobenzyl-3-[3-tert-butylsulfanyl-5-(methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester 
• 936350-00-4 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid 
• 1196965-16-8 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester 
• 154325-77-6 ethyl 3-[1-(4-chlorobenzyl)-3-(1,1-dimethylethylthio)-5-hydroxyindol-2-yl]-2,2-dimethylpropionate 
• 936349-47-2 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid 
• 936349-15-4 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester 
• 1146961-35-4 ethyl 3-[3-(tert-butylthio)-6-methoxy-1H-indol-2-yl]-2,2-dimethylpropanoate 

Relevant articles and documents

COMPOUNDS AND METHODS FOR TREATMENT OF HEDGEHOG PATHWAY ASSOCIATED CONDITIONS

Provided herein is novel compounds of formula (I), (II), (III), (IV), and (V) as described in the specification, and pharmaceutically acceptable salts, solvates, and prodrugs and compositions thereof, and methods of measuring hedgehog pathway activation in tumor cells, examining tumor cell proliferation, differentiation and apoptosis and using the compounds and pharmaceutical compositions disclosed for treatment of diseases and disorders associated with the hedgehog signaling pathway.

New-type compound and preparation method and application thereof

The invention relates to a new-type compound. A structural formula of the new-type compound is as shown in a formula (1). The invention further provides a method for preparing the above new-type compound. The invention further provides an application of the above new-type compound or pharmaceutically acceptable salt thereof, a solvate or a drug compound for preparing a drug for treating a diseaserelated to activation of a hedgehog passage. The provided above new-type compound can be used for preparing the drug for treating the disease related to the activation of the hedgehog passage. The new-type compound is particularly capable of inhibiting growth of medulloblastoma well, and can be used for preparing a drug for treating medulloblastoma related diseases.

Facile synthesis of trisubstituted thioindoles via a novel tricyclic thiolactone intermediate

Methodology to conveniently and systematically prepare biologically active indole 9 is described. Copyright Taylor & Francis Group, LLC.