1365645-08-4

Upstream product

• 88-15-3 2-Acetylthiophene 
• 18234-50-9 3-(2-hydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one 
• 90-02-8 salicylaldehyde 

Downstream Products

• 1365645-12-0 C₁₃H₉NO₂S 

Relevant academic research and scientific papers

Synthesis of 3,5-disubstituted isoxazolines and isoxazoles

2-Acetylthiophene condenses with different aromatic aldehyde in ethanol in the presence of aqueous NaOH to give 1-(2′thienyl)-3-(substituted phenyl)-2-propen-1-one(Ia-e) which reacts with hydroxylamine hydrochloride and aqueous KOH in presence of ethonal medium to give 3-(2′-thienyl)-5- (substituted phenyl)-2-isoxazoline (IIa-e). And 3-(2′-thienyl)- 5-(substituted phenyl)-Δ2-isoxazoline (IIa-e) was dissolved in DMSO. To this catalytic amount of iodine was added. Cooled and diluted with water. The solid thus separated was washed with 20% sodium thiosulphate to give 3-(2′-thienyl)-5-(substituted phenyl)-isoxazole (II′a-e). Characterization and structural elucidation were done on the basis of melting points determination, analytical and spectral studies.