136565-60-1

Basic information

• Product Name: L-α-Dilauroyl Phosphatidylcholine-d46
• Synonyms: L-α-Dilauroyl Phosphatidylcholine-d46
• CAS NO: 136565-60-1
• Molecular Formula: C32H64NO8P
• Molecular Weight: 621.826221
• Product Categories: Isotope Labelled Compounds, Miscellaneous Reagents, Phosphorylating and Phosphitylating Agents
• Mol File: 136565-60-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: L-α-Dilauroyl Phosphatidylcholine-d46(CAS DataBase Reference)
• NIST Chemistry Reference: L-α-Dilauroyl Phosphatidylcholine-d46(136565-60-1)
• EPA Substance Registry System: L-α-Dilauroyl Phosphatidylcholine-d46(136565-60-1)

Safety Data

• Hazardous Substances Data: 136565-60-1(Hazardous Substances Data)

Usage

Description

L-α-Dilauroyl Phosphatidylcholine-d46, also known as DLPC-d46, is a synthetic, deuterated phospholipid that is commonly used in the field of biophysics and molecular biology. It is a derivative of L-α-Dilauroyl Phosphatidylcholine, with 46 deuterium atoms incorporated into its structure. DLPC-d46 is known for its ability to form robust and versatile membrane bilayers, which are essential for various biophysical and cellular studies.

Uses

1. Used in Biophysics and Molecular Biology Research:
L-α-Dilauroyl Phosphatidylcholine-d46 is used as a model membrane for studying the selective and ATP-driven transport of ions across membranes into nanoporous carriers. This application is particularly important for understanding the mechanisms of ion transport and the role of membrane proteins, such as gramicidin A and ATP synthase, in these processes.
2. Used in the Preparation of Other Phosphatidylcholines:
DLPC-d46 is also utilized in the synthesis and preparation of other phosphatidylcholine derivatives. These derivatives can have various applications in different fields, such as pharmaceuticals, drug delivery, and cosmetics.
3. Used in Drug Delivery Systems:
In the pharmaceutical industry, L-α-Dilauroyl Phosphatidylcholine-d46 can be used as a component in the development of drug delivery systems. Its ability to form stable membrane bilayers makes it a valuable tool for designing and optimizing drug carriers, such as liposomes and nanoparticles, which can improve the delivery, bioavailability, and therapeutic outcomes of various drugs.
4. Used in Cosmetics:
In the cosmetics industry, DLPC-d46 may be used as an ingredient in skincare and beauty products due to its potential benefits for the skin, such as moisturization and barrier function enhancement. Its ability to form stable lipid bilayers could contribute to the development of more effective and targeted cosmetic formulations.

Relevant articles and documents

Elastic deformation of membrane bilayers probed by deuterium NMR relaxation

In deuterium (2H) NMR spectroscopy of fluid lipid bilayers, the average structure is manifested in the segmental order parameters (SCD) of the flexible molecules. The corresponding spin-lattice relaxation rates (R1Z) depend on both the amplitudes and the rates of the segmental fluctuations, and indicate the types of lipid motions. By combining 2H NMR order parameter measurements with relaxation studies, we have obtained a more comprehensive picture of lipids in the liquid-crystalline (Lα) state than formerly possible. Our data suggest that a lipid bilayer constitutes an ordered fluid, in which the phospholipids are grafted to the aqueous interface via their polar headgroups, whereas the fatty acyl chains are in effect liquid hydrocarbon. Studies of 2H-labeled saturated lipids indicate their R1Z rates and SCD order parameters are correlated by a model-free, square-law functional dependence, signifying the presence of relatively slow bilayer fluctuations. A new composite membrane deformation model explains simultaneously the frequency (magnetic field) dependence and the angular anisotropy of the relaxation. The results imply the R1Z rates are due to a broad spectrum of 3-D collective bilayer excitations, together with effective axial rotations of the lipids. For the first time, NMR relaxation studies show that the viscoelastic properties of membrane lipids at megahertz frequencies are modulated by the lipid acyl length (bilayer thickness), polar headgroups (bilayer interfacial area), inclusion of a nonionic detergent (C12E8), and the presence of cholesterol, leading to a range of bilayer softness. Our findings imply the concept of elastic deformation is relevant on lengths approaching the bilayer thickness and less (the mesoscopic scale), and suggest that application of combined R12 and SCD studies of phospholipids can be used as a simple membrane elastometer. Heuristic estimates of the bilayer bending rigidity κ and the area elastic modulus Ka enable comparison to other biophysical studies, involving macroscopic deformation of thin membrane lipid films. Finally, the bilayer softness may be correlated with the lipid diversity of biomembranes, for example, with regard to membrane curvature, repulsive interactions between bilayers, and lipid-protein interactions.