t-Boc-N-amido-PEG2-acid is a PEG (polyethylene glycol) linker that features a terminal carboxylic acid and a Boc-protected amino group. This molecule is designed to enhance solubility in aqueous media due to the hydrophilic PEG spacer. The terminal carboxylic acid can form a stable amide bond with primary amine groups when activated by agents such as EDC or HATU. Additionally, the Boc group can be removed under mild acidic conditions, revealing the free amine.
1365655-91-9
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Basic information
- Product Name: t-Boc-N-amido-PEG2-acid
- Synonyms: t-Boc-N-amido-PEG2-acid;N-Boc-3-[2-(2-aminoethoxy)ethoxy]propionic Acid;Boc-N-amido-PEG2-acid;3-[2-(2-([(tert-Butoxy)carbonyl]amino)ethoxy)ethoxy]propanoic acid;t-boc-N-amido-PEG2-propionic acid;Boc-NH-PEG2-COOH
- CAS NO:1365655-91-9
- Molecular Formula: C12H23NO6
- Molecular Weight: 277.31412
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1365655-91-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 429.9±35.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.125±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: N/A
- PKA: 4.28±0.10(Predicted)
- CAS DataBase Reference: t-Boc-N-amido-PEG2-acid(CAS DataBase Reference)
- NIST Chemistry Reference: t-Boc-N-amido-PEG2-acid(1365655-91-9)
- EPA Substance Registry System: t-Boc-N-amido-PEG2-acid(1365655-91-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1365655-91-9(Hazardous Substances Data)
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1365655-91-9 Usage
Uses
Used in Bioconjugation:t-Boc-N-amido-PEG2-acid is used as a bioconjugation agent for the formation of stable amide bonds between molecules. The application reason is its ability to react with primary amine groups in the presence of activators, creating a stable linkage that can be useful in various biological and chemical applications.
Used in Drug Delivery Systems:
In the pharmaceutical industry, t-Boc-N-amido-PEG2-acid is used as a component in drug delivery systems to improve the solubility and bioavailability of drugs. The reason for its use is the hydrophilic PEG spacer, which can enhance the water solubility of the drug and facilitate its transport through the body.
Used in Protein Modification:
t-Boc-N-amido-PEG2-acid is used as a protein modification agent to introduce PEGylation, a process that can improve the stability, solubility, and half-life of proteins in biological systems. The application reason is the ability to form stable amide bonds with primary amine groups on the protein, and the Boc protection allows for selective deprotection and modification.
Used in Chemical Synthesis:
In the field of chemical synthesis, t-Boc-N-amido-PEG2-acid is used as an intermediate for the synthesis of various PEGylated compounds. The application reason is its versatile reactivity, allowing for the creation of a wide range of PEGylated products with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1365655-91-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,5,6,5 and 5 respectively; the second part has 2 digits, 9 and 1 respectively.Calculate Digit Verification of CAS Registry Number 1365655-91:
(9*1)+(8*3)+(7*6)+(6*5)+(5*6)+(4*5)+(3*5)+(2*9)+(1*1)=189
189 % 10 = 9
So 1365655-91-9 is a valid CAS Registry Number.
1365655-91-9Upstream product
1365655-91-9Downstream Products
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t-Boc-N-amido-PEG2-acid
